Structural, Spectroscopic, Molecular Docking and Biological Evaluation of some Novel Benzofuran Derivatives
نویسندگان
چکیده
Benzofurans display a wide array of pharmaceutical activities. The present work incorporates the synthesis some novel benzofuran derivatives. compound 1 (z)-3-amino-7methoxy-N1-(2-oxoindolin-3-yliedene)benzofuran-2-carbohydrazide was synthesized by refluxing carbohydrazide and isatin. formed key intermediate for compounds 2a-c. structures prepared derivatives were established physical spectral methods such as elemental analysis, FTIR, 1HNMR Mass. molecular docking studies performed to detect behavior towards target proteins. further screened antibacterial antifungal analysis.
منابع مشابه
Synthesis, Biological Evaluation and Docking Analysis of Some Novel Quinazolin Derivatives as Antitumor Agents
Different acid chlorides (2a-d) reacted with anthranilic acid to produce 2-substituted-3, 1-benzoxazin-4-one (3a-d) which was used as starting material to synthesize some condensed and non-condensed heterocyclic compounds by reaction with nitrogen nucleophiles e.g., hydrazine hydrate, and formamide. Some of the newly synthesized analogues were chosen to evaluate their cytotoxic activity against...
متن کاملSynthesis, Biological Evaluation and Docking Analysis of Some Novel Quinazolin Derivatives as Antitumor Agents
Different acid chlorides (2a-d) reacted with anthranilic acid to produce 2-substituted-3, 1-benzoxazin-4-one (3a-d) which was used as starting material to synthesize some condensed and non-condensed heterocyclic compounds by reaction with nitrogen nucleophiles e.g., hydrazine hydrate, and formamide. Some of the newly synthesized analogues were chosen to evaluate their cytotoxic activity against...
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different acid chlorides (2a-d) reacted with anthranilic acid to produce 2-substituted-3, 1-benzoxazin-4-one (3a-d) which was used as starting material to synthesize some condensed and non-condensed heterocyclic compounds by reaction with nitrogen nucleophiles e.g., hydrazine hydrate, and formamide. some of the newly synthesized analogues were chosen to evaluate their cytotoxic activity against...
متن کاملSynthesis, Biological Evaluation and Docking Analysis of Some Novel Quinazolin Derivatives as Antitumor Agents
Different acid chlorides (2a-d) reacted with anthranilic acid to produce 2-substituted-3, 1-benzoxazin-4-one (3a-d) which was used as starting material to synthesize some condensed and non-condensed heterocyclic compounds by reaction with nitrogen nucleophiles e.g., hydrazine hydrate, and formamide. Some of the newly synthesized analogues were chosen to evaluate their cytotoxic activity against...
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ژورنال
عنوان ژورنال: Oriental journal of chemistry
سال: 2022
ISSN: ['0970-020X', '2231-5039']
DOI: https://doi.org/10.13005/ojc/380623